ReguGene Co., Ltd. is a pharmaceutical venture company founded on 3rd Sep 2018 by Professor Hiroshi Sugiyama at Graduate School of Science of Kyoto University and Professor Yasuhiko Kamikubo at Graduate School of Medicine of Kyoto University. Our aim is to supply medicines for intractable and rare diseases by developing DNA-targeting drugs utilizing cell permeable pyrrole-imidazole polyamides.Detail
Pyrrole-Imidazole Polyamides (PI-Polyamides) are synthetic molecules developed by mimicking the structures of natural antibiotics, netropsin and distamycin. They have simple structures consisting of N-methylpyrrole, N-methylimidazole, and -alanine connected by amide bonds. Hairpin-shaped PI-Polyamides are often used to design to bind to a specific target DNA sequence. Professor Hiroshi Sugiyama has researched PI-Polyamides for more than 20 years and possesses methods and know-hows for the synthesis and evaluation of the activities.
PI-Polyamides as ON/OFF Switch of genes
PI-Polyamides which bind to a recognition sequence of a transcription factor can inhibit the binding of the transcription factor to DNA in live cells and suppress the transcription of the gene activated by the transcription factor (OFF switch). Conjugation of a DNA alkylating reagent with PI-Polyamides enables to suppress transcription even if their target sequences are not a binding site of a transcription factor.
Professor Hiroshi Sugiyama has also succeeded to enhance expression levels of gene clusters by using PI-Polyamides conjugates with HDAC inhibitor, HAT activator, and bromodomain inhibitor of HAT (ON switch).
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2020-03-302020/3/30 Extension of Incubation Program (Kyoto University) “Drug Development Project Based on Pyrrole-Imidazole Polyamide Conjugates with Specific DNA Binding Capability” for 1 year was approved.
2020-02-272020/2/27–28 Ikeda participated in Kyoto University LifeScience ShowCase @UCSD2020 (UCSD, San Diego, US).
2020-01-232020/1/23 Ikeda talked at the pitch of Kyoto Star Creation Project (Kyoto Economy Center).